GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs12780845 | 1 | rs56394211 | chr10:17186447 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.76 | 6.83E-6 | Homocysteine levels |
| THYM | cis | rs477692 | 1 | rs565974 | chr10:131423274 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs9309473 | 1 | rs56672945 | chr2:73622663 | ALMS1P | chr2:73872046-73912692:+ | 0.62 | 4.72 | 8.01E-6 | Metabolite levels |
| THYM | cis | rs6911965 | 1 | rs56763150 | chr6:24482999 | ALDH5A1 | chr6:24495197-24537434:+ | 0.33 | 4.16 | 7.04E-5 | Hematological and biochemical traits |
| THYM | cis | rs6911965 | 1 | rs56763150 | chr6:24482999 | GPLD1 | chr6:24428405-24489850:- | 0.56 | 5.51 | 3.04E-7 | Hematological and biochemical traits |
| THYM | cis | rs477692 | 1 | rs567700 | chr10:131423126 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs56775891 | 1 | rs56775891 | chr18:77575613 | KCNG2 | chr18:77623668-77659815:+ | 0.59 | 4.5 | 1.9E-5 | Schizophrenia |
| THYM | cis | rs9815354 | 1 | rs56776628 | chr3:41866856 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs568617 | 1 | rs568617 | chr11:65653242 | CTSW | chr11:65647284-65651212:+ | -0.59 | -7.12 | 2.04E-10 | Crohn's disease |
| THYM | cis | rs568617 | 1 | rs568617 | chr11:65653242 | SNX32 | chr11:65601410-65621170:+ | 0.55 | 5.17 | 1.29E-6 | Crohn's disease |
| THYM | cis | rs8078723 | 1 | rs56922390 | chr17:38157021 | GSDMA | chr17:38119226-38134019:+ | -0.89 | -9.76 | 5.45E-16 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs477692 | 1 | rs569235 | chr10:131411620 | MGMT | chr10:131265454-131565783:+ | 0.3 | 4.15 | 7.2E-5 | Response to temozolomide |
| THYM | cis | rs2243480 | 1 | rs56985706 | chr7:65394562 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.9 | 3.88E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs57057549 | chr7:65405738 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.29 | 7.77E-7 | Diabetic kidney disease |
| THYM | cis | rs2143950 | 1 | rs57075379 | chr14:35577801 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.14 | 7.59E-5 | Atopic dermatitis |